Critical appraisal:Ell C, May A, Pech O, Gossner L, Guenter E, Behrens A, et al 2007 2

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Critical Appraisal

Article being appraised

Ell C, May A, Pech O, Gossner L, Guenter E, Behrens A, et al. Curative endoscopic resection of early esophageal adenocarcinomas (Barrett's cancer). Gastrointest Endosc 2007 Jan;65(1):3-10 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/17185072.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

100


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: This is a single-centre prospective series of 100 patients. This was a non-blinded study but objective measures such as complete local remission and complications such as bleeding were reported.

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: The size of the effect was not assessable as statistical significance was not reported.
Relevance of evidence
1 Additional comments: This study reported on patient survival with a calculated 5-year survival rate was 98% (2 patients died of other causes).
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Jeremy Dwyer MBBS (Hons)


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Article
Ell C, May A, Pech O, Gossner L, Guenter E, Behrens A, et al. Curative endoscopic resection of early esophageal adenocarcinomas (Barrett's cancer). Gastrointest Endosc 2007 Jan;65(1):3-10 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/17185072.
Assigned to
User:Alan.moss
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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