Critical appraisal:Ertan A, Zaheer I, Correa AM, Thosani N, Blackmon SH 2013 2

From Clinical Guidelines Wiki

Critical Appraisal

Article being appraised

Ertan A, Zaheer I, Correa AM, Thosani N, Blackmon SH. Photodynamic therapy vs radiofrequency ablation for Barrett's dysplasia: Efficacy, safety and cost-comparison. World J Gastroenterol 2013 Nov 7;19(41):7106-13 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/24222954.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

80


Includes an economic evaluation

yes

Evidence ratings

Level of evidence

III-3

Risk of bias
High risk of bias Comments: Major deficiency is the major difference on the rates of HGD v LGD in the PDT and RFA groups (HGD/LGD = 33/0 in PDT , 6/47 in RFA)

Risk of bias assessment: cohort study

Subject selection
"New technology" group
Representative of eligible patients.
Comparison group
Representative of eligible patients
Comparability of groups on demographic characteristics and clinical features
Not comparable and not adjusted for differences
Measurement of outcomes
Outcome measures blind to technology used
No, but objective measures used
Same method of measurement used across comparison groups
Yes
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
Reasonable follow-up of all groups (>80%)
Size of effect
1 Reason for decision: large effect but really not a valid comparison because of difference in HGD v LGD rate
Relevance of evidence
2 Additional comments: historical cohort study which provides data on relevant marker
Result of appraisal

Jutta's tick icon.png Included



Comments

Relevant and interesting study though comparison really not valid esp with LGD v HGD differences

Completed by

Dr Andrew Taylor MBBS MD FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Ertan A, Zaheer I, Correa AM, Thosani N, Blackmon SH. Photodynamic therapy vs radiofrequency ablation for Barrett's dysplasia: Efficacy, safety and cost-comparison. World J Gastroenterol 2013 Nov 7;19(41):7106-13 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/24222954.
Assigned to
User:Andrew.taylor
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment