Critical appraisal:Faybush EM, Sampliner RE 2005 3

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Critical Appraisal

Article being appraised

Faybush EM, Sampliner RE. Randomized trials in the treatment of Barrett's esophagus. Dis Esophagus 2005;18(5):291-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/16197527.


Applicable clinical question

Key Facts

Study Design

systematic review — review of 8 randomised trials comparing treatment for BE from 1996-2005. 8 trials with different entry criteria and endpoints, comparing a variety of treaments

Number of Patients:

430


Includes an economic evaluation

no

Evidence ratings

Level of evidence

I

Risk of bias
High risk of bias Comments: mixed bag of largely small trials with varying endpoints. Data is now out of date

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Adequate – search terms and/or choice of databases could have been improved upon
Were the inclusion criteria appropriate and applied in an unbiased way?
Adequate – inclusion criteria were pre-specified and applied by one person
Were the studies assessed for quality (relating to the minimisation of biases)?
No – quality assessment either not undertaken, inappropriate or not described
Were the characteristics and results of individual studies appropriately summarised?
Adequate – more information would be desirable
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
No response
If there was heterogeneity, were sources of heterogeneity explored?
No response
Size of effect
5 Reason for decision: can only assess effect of individual trials population to different to estimate effect of review article
Relevance of evidence
4 Additional comments: Only one trial included HGD in BE. This had follow up to 24 months and showed reductio n in progression to cancer (13% vs 28%)
Result of appraisal

Jutta's tick icon.png Included




Completed by

Associate Professor Bernard Mark Smithers


Jutta's tick icon.png This appraisal has been completed.


Article
Faybush EM, Sampliner RE. Randomized trials in the treatment of Barrett's esophagus. Dis Esophagus 2005;18(5):291-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/16197527.
Assigned to
User:Bernard.smithers
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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