Critical appraisal:Frazzoni M, Manno M, De Micheli E, Savarino V 2007

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Critical Appraisal

Article being appraised

Frazzoni M, Manno M, De Micheli E, Savarino V. Efficacy in intra-oesophageal acid suppression may decrease after 2-year continuous treatment with proton pump inhibitors. Dig Liver Dis 2007 May;39(5):415-21 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/17379591.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

45


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Followup of a group of patients with Barretts and severe reflux over a 2 year period. some may have participated in the previously published trial. No protocol stated for use of medication or dose escalation.

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No or not described
Follow-up complete and all patients included in the analysis?
Reasonable (follow-up >80%)
Size of effect
5 Reason for decision: Pre-post comparison was available and showed that all patients, having previously had symptoms, were now controlled. No formal statistical testing done on this comparison
Relevance of evidence
5 Additional comments: main focus was on pH metry
Result of appraisal

Jutta's tick icon.png Included



Comments

Shows that a range of PPIs/doses can achieve symptom control in a selected series of patients

Completed by

Associate Professor Geoffrey Hebbard


Jutta's tick icon.png This appraisal has been completed.


Article
Frazzoni M, Manno M, De Micheli E, Savarino V. Efficacy in intra-oesophageal acid suppression may decrease after 2-year continuous treatment with proton pump inhibitors. Dig Liver Dis 2007 May;39(5):415-21 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/17379591.
Assigned to
User:Geoffrey.hebbard
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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