Critical appraisal:Frazzoni M, Savarino E, Manno M, Melotti G, Mirante VG, Mussetto A, et al 2009

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Critical Appraisal

Article being appraised

Frazzoni M, Savarino E, Manno M, Melotti G, Mirante VG, Mussetto A, et al. Reflux patterns in patients with short-segment Barrett's oesophagus: a study using impedance-pH monitoring off and on proton pump inhibitor therapy. Aliment Pharmacol Ther 2009 Sep 1;30(5):508-15 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19519732.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

51


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Primary aim of the study was to examine for ongoing reflux in SSBE patients on therapy adjusted to control symptoms

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No or not described
Follow-up complete and all patients included in the analysis?
Reasonable (follow-up >80%)
Size of effect
1 Reason for decision: Off and on Esomeprazole 40mg symptom analysis indicates a major effect of PPI in controlling symptoms
Relevance of evidence
3 Additional comments: Symptoms were not the focus of the study, but 40/51 patients were symptomatic off PPI and all controlled on esomeprazole 40mg
Result of appraisal

Jutta's tick icon.png Included



Comments

All patients symptoms were able to be controlled on esomeprazole 40mg

Completed by

Associate Professor Geoffrey Hebbard


Jutta's tick icon.png This appraisal has been completed.


Article
Frazzoni M, Savarino E, Manno M, Melotti G, Mirante VG, Mussetto A, et al. Reflux patterns in patients with short-segment Barrett's oesophagus: a study using impedance-pH monitoring off and on proton pump inhibitor therapy. Aliment Pharmacol Ther 2009 Sep 1;30(5):508-15 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19519732.
Assigned to
User:Geoffrey.hebbard
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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