Critical appraisal:Gaddam S, Singh M, Balasubramanian G, Gupta N, Wani S, Higbee AD, et al 2013

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Critical Appraisal

Article being appraised

Gaddam S, Singh M, Balasubramanian G, Gupta N, Wani S, Higbee AD, et al. Persistence of Non-Dysplastic Barrett's Esophagus Identifies Patients at Lower Risk for Esophageal Adenocarcinoma-Results from a Large Multicenter Cohort. Gastroenterology 2013 May 25 Available from: http://www.ncbi.nlm.nih.gov/pubmed/23714382.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

2323


Includes an economic evaluation

no

Evidence ratings

Risk of bias
Moderate risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: prevalence and incidence study

Source population of patients
Selected group (multiple institutions)
Subject (sample) selection
Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Reasonable follow-up (>80%)
Result of appraisal

Jutta's tick icon.png Included



Comments

group 1 were found to have
NDBE at their first esophagogastroduodenoscopy (EGD).
Patients in group 2 were found to have NDBE on their
first 2 consecutive EGDs. Similarly, patients in groups 3, 4,
and 5 were found to have NDBE on 3, 4, and 5 consecutive
surveillance EGDs. The annual risk of EAC in groups 1
to 5 was 0.32%, 0.27%, 0.16%, 0.2%, and 0.11%, respectively
(P for trend = .03). After adjusting for age, sex, and length
of BE, persistence of NDBE, based on multiple surveillance
endoscopies, was associated with a gradually lower
likelihood of progression to EAC.

Completed by

Associate Professor Freddy Sitas


Jutta's tick icon.png This appraisal has been completed.


Article
Gaddam S, Singh M, Balasubramanian G, Gupta N, Wani S, Higbee AD, et al. Persistence of Non-Dysplastic Barrett's Esophagus Identifies Patients at Lower Risk for Esophageal Adenocarcinoma-Results from a Large Multicenter Cohort. Gastroenterology 2013 May 25 Available from: http://www.ncbi.nlm.nih.gov/pubmed/23714382.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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