Critical appraisal:Gaddam S, Singh M, Balasubramanian G, Gupta N, Wani S, Higbee AD, et al 2013
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Critical Appraisal
Article being appraised
Gaddam S, Singh M, Balasubramanian G, Gupta N, Wani S, Higbee AD, et al. Persistence of Non-Dysplastic Barrett's Esophagus Identifies Patients at Lower Risk for Esophageal Adenocarcinoma-Results from a Large Multicenter Cohort. Gastroenterology 2013 May 25 Available from: http://www.ncbi.nlm.nih.gov/pubmed/23714382.
Applicable clinical question
Key Facts
Study Design
prevalence and incidence study
Number of Patients:
2323
Includes an economic evaluation
no
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Risk of bias
| Moderate risk of bias | Comments: Please replace this text and include any additional comments in regards to your quality rating |
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- Article
- Gaddam S, Singh M, Balasubramanian G, Gupta N, Wani S, Higbee AD, et al. Persistence of Non-Dysplastic Barrett's Esophagus Identifies Patients at Lower Risk for Esophageal Adenocarcinoma-Results from a Large Multicenter Cohort. Gastroenterology 2013 May 25 Available from: http://www.ncbi.nlm.nih.gov/pubmed/23714382.
- Assigned to
- User:Freddy.sitas
- Topic area
- Guidelines:Barrett's
- Clinical question
Section below only relevant for Cancer Council Project Officer
group 1 were found to have
NDBE at their first esophagogastroduodenoscopy (EGD).
Patients in group 2 were found to have NDBE on their
first 2 consecutive EGDs. Similarly, patients in groups 3, 4,
and 5 were found to have NDBE on 3, 4, and 5 consecutive
surveillance EGDs. The annual risk of EAC in groups 1
to 5 was 0.32%, 0.27%, 0.16%, 0.2%, and 0.11%, respectively
(P for trend = .03). After adjusting for age, sex, and length
of BE, persistence of NDBE, based on multiple surveillance
endoscopies, was associated with a gradually lower
likelihood of progression to EAC.