Critical appraisal:Gatenby PA, Caygill CP, Ramus JR, Charlett A, Fitzgerald RC, Watson A 2007

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Critical Appraisal

Article being appraised

Gatenby PA, Caygill CP, Ramus JR, Charlett A, Fitzgerald RC, Watson A. Short segment columnar-lined oesophagus: an underestimated cancer risk? A large cohort study of the relationship between Barrett's columnar-lined oesophagus segment length and adenocarcinoma risk. Eur J Gastroenterol Hepatol 2007 Nov;19(11):969-75 Available from: http://www.ncbi.nlm.nih.gov/pubmed/18049166.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

781



Evidence ratings

Risk of bias
Moderate risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: prevalence and incidence study

Source population of patients
Selected group (multiple institutions)
Subject (sample) selection
Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Reasonable follow-up (>80%)
Result of appraisal

Jutta's tick icon.png Included



Comments

UK National Barrett’s Oesophagus Registry (UKBOR). The overall annual adenocarcinoma incidence
was 0.62%/year (95% confidence interval: 0.36–1.01). The annual incidence in the segment length groups was 0.59% (0.19–1.37) in short segment (r3 cm), 0.099% (0.025–0.55) in > 3 r6 cm, 0.98% (0.27–2.52) in >6 r9 cm and 2.0% (0.73–4.35) in > 9 cm; P = 0.004.

Completed by

Associate Professor Freddy Sitas


Jutta's tick icon.png This appraisal has been completed.


Article
Gatenby PA, Caygill CP, Ramus JR, Charlett A, Fitzgerald RC, Watson A. Short segment columnar-lined oesophagus: an underestimated cancer risk? A large cohort study of the relationship between Barrett's columnar-lined oesophagus segment length and adenocarcinoma risk. Eur J Gastroenterol Hepatol 2007 Nov;19(11):969-75 Available from: http://www.ncbi.nlm.nih.gov/pubmed/18049166.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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