Critical appraisal:Gelber RD, Larson M, Borgelt BB, Kramer S 1981

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Critical Appraisal

Article being appraised

Gelber RD, Larson M, Borgelt BB, Kramer S. Equivalence of radiation schedules for the palliative treatment of brain metastases in patients with favorable prognosis. Cancer 1981 Oct 15;48(8):1749-53 Available from: http://www.ncbi.nlm.nih.gov/pubmed/6169424.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

561


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
Low risk of bias Comments: This is a reanalysis of the RTOG trial examining different fractionation schemes, already included in the evidence. However this analysis focuses on patients with favourable prognosis.


Size of effect
1 Reason for decision: Equivalence trial. Showed no difference in clinical outcomes in patients with "good prognosis" brain mets from lung cancer with respect to different RT fractionation schedules.
Relevance of evidence
1 Additional comments: Patient relevant clinical outcomes measured ie palliative effectiveness - median time to progression, neurological control, survival
Result of appraisal

Jutta's tick icon.png Included




Completed by

Associate Professor Shalini Vinod MBBS MD FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Gelber RD, Larson M, Borgelt BB, Kramer S. Equivalence of radiation schedules for the palliative treatment of brain metastases in patients with favorable prognosis. Cancer 1981 Oct 15;48(8):1749-53 Available from: http://www.ncbi.nlm.nih.gov/pubmed/6169424.
Assigned to
User:Shalini.vinod
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
Clinical question
Form
Form:Critical appraisal


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