Critical appraisal:Gelber RD, Larson M, Borgelt BB, Kramer S 1981
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Critical Appraisal
Article being appraised
Gelber RD, Larson M, Borgelt BB, Kramer S. Equivalence of radiation schedules for the palliative treatment of brain metastases in patients with favorable prognosis. Cancer 1981 Oct 15;48(8):1749-53 Available from: http://www.ncbi.nlm.nih.gov/pubmed/6169424.
Applicable clinical question
Key Facts
Study Design
randomised controlled trial
Number of Patients:
561
Includes an economic evaluation
no
Evidence ratings
Level of evidence
II
Risk of bias
| Low risk of bias | Comments: This is a reanalysis of the RTOG trial examining different fractionation schemes, already included in the evidence. However this analysis focuses on patients with favourable prognosis. |
Size of effect
| 1 | Reason for decision: Equivalence trial. Showed no difference in clinical outcomes in patients with "good prognosis" brain mets from lung cancer with respect to different RT fractionation schedules. |
Relevance of evidence
| 1 | Additional comments: Patient relevant clinical outcomes measured ie palliative effectiveness - median time to progression, neurological control, survival |
Result of appraisal
Included
Completed by
This appraisal has been completed.
- Article
- Gelber RD, Larson M, Borgelt BB, Kramer S. Equivalence of radiation schedules for the palliative treatment of brain metastases in patients with favorable prognosis. Cancer 1981 Oct 15;48(8):1749-53 Available from: http://www.ncbi.nlm.nih.gov/pubmed/6169424.
- Assigned to
- User:Shalini.vinod
- Topic area
- Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
- Clinical question
Section below only relevant for Cancer Council Project Officer