Critical appraisal:Gellert SE, Pors SE, Kristensen SG, Bay-Bjørn AM, Ernst E, Yding Andersen C 2018

Critical Appraisal

Article being appraised

Gellert SE, Pors SE, Kristensen SG, Bay-Bjørn AM, Ernst E, Yding Andersen C. Transplantation of frozen-thawed ovarian tissue: an update on worldwide activity published in peer-reviewed papers and on the Danish cohort. J Assist Reprod Genet 2018 Apr;35(4):561-570 Available from: http://www.ncbi.nlm.nih.gov/pubmed/29497953.

Applicable clinical question

• In female cancer patients does ovarian tissue cryopreservation result in pregnancy and livebirth? Is there any reduction in the quality of oocytes/follicles? Can transplantation restore pubertal development? Are there any risks involved?

Key Facts

Study Design

systematic review — review of multiple case reprots

Number of Patients:

360

Evidence ratings

Level of evidence

IV

Risk of bias

Low risk of bias

Comments:

Size of effect

5	Reason for decision:

Relevance of evidence

1	Additional comments:

Result of appraisal

Included

Completed by

Dr Jessica Harris

This appraisal has been completed.

Article

Gellert SE, Pors SE, Kristensen SG, Bay-Bjørn AM, Ernst E, Yding Andersen C. Transplantation of frozen-thawed ovarian tissue: an update on worldwide activity published in peer-reviewed papers and on the Danish cohort. J Assist Reprod Genet 2018 Apr;35(4):561-570 Available from: http://www.ncbi.nlm.nih.gov/pubmed/29497953.

Assigned to

User:Kate.stern

Topic area

Guidelines:COSA:Cancer fertility preservation guidelines/Options for treatment

Clinical question

• In female cancer patients does ovarian tissue cryopreservation result in pregnancy and livebirth? Is there any reduction in the quality of oocytes/follicles? Can transplantation restore pubertal development? Are there any risks involved?

Form

Form:Critical appraisal

Section below only relevant for Cancer Council Project Officer

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