Critical appraisal:Germain F, Wai ES, Berthelet E, Truong PT, Lesperance M 2008

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Critical Appraisal

Article being appraised

Germain F, Wai ES, Berthelet E, Truong PT, Lesperance M. Brain metastasis is an early manifestation of distant failure in stage III nonsmall cell lung cancer patients treated with radical chemoradiation therapy. Am J Clin Oncol 2008 Dec;31(6):561-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/19060588.


Applicable clinical question

Key Facts

Study Design

other — Population database series of patients treated with chemoRT for Stage III NSCLC

Number of Patients:

120


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
Moderate risk of bias Comments: Population based series of patients treated with chemoRT for Stage III NSCLC examining patterns of failure ie brain relapse


Size of effect
4 Reason for decision: This is not relevant. This paper shows the brain relapse in a series of patients treated with chemoRT for Stage III NSCLC was 27%. Not about effect of treatment.
Relevance of evidence
3 Additional comments: This is just a background paper for incidence of brain metastases.
Result of appraisal

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Completed by

Associate Professor Shalini Vinod MBBS MD FRANZCR


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Article
Germain F, Wai ES, Berthelet E, Truong PT, Lesperance M. Brain metastasis is an early manifestation of distant failure in stage III nonsmall cell lung cancer patients treated with radical chemoradiation therapy. Am J Clin Oncol 2008 Dec;31(6):561-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/19060588.
Assigned to
User:Shalini.vinod
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
Clinical question
Form
Form:Critical appraisal


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