Critical appraisal:Gladman L, Chapman W, Iqbal TH, Gearty JC, Cooper BT 2006

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Critical Appraisal

Article being appraised

Gladman L, Chapman W, Iqbal TH, Gearty JC, Cooper BT. Barrett's oesophagus: an audit of surveillance over a 17-year period. Eur J Gastroenterol Hepatol 2006 Mar;18(3):271-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/16462540.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

195



Evidence ratings

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: prevalence and incidence study

Source population of patients
Highly selected (single institution) or not described
Subject (sample) selection
Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Reasonable follow-up (>80%)
Result of appraisal

Jutta's tick icon.png Included



Comments

"Virtually all" of the pathology was done by a single author of the study, a pathologist. Is this an issue?

32/195 (16%) patients were lost to follow up/refused further follow up/left the area.

"average" follow up time of 5.5 years.
4 out of the 195 patients developed oesophageal adenocarcinoma.
3.7 cases per 1000 patient-years.
Incidence of 0.37%.
Confidence intervals not reported.
1 additional patient developed squamous cell carcinoma of the oesophagus.

Completed by

Peter Sarich


Jutta's tick icon.png This appraisal has been completed.


Article
Gladman L, Chapman W, Iqbal TH, Gearty JC, Cooper BT. Barrett's oesophagus: an audit of surveillance over a 17-year period. Eur J Gastroenterol Hepatol 2006 Mar;18(3):271-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/16462540.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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