Critical appraisal:Guadagnolo BA, Prieto V, Weber R, Ross MI, Zagars GK 2014 3

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Critical Appraisal

Article being appraised

Guadagnolo BA, Prieto V, Weber R, Ross MI, Zagars GK. The role of adjuvant radiotherapy in the local management of desmoplastic melanoma. Cancer 2014 May 1;120(9):1361-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/24142803.


Applicable clinical question

Key Facts

Study Design

cohort study

Study aims:

To evaluate outcomes, specifically with respect to adjuvant radiotherapy (RT), for patients with desmoplastic melanoma

Number of Patients:

130

Note that 56 patients underwent sentinel lymph node biopsy.
Results of outcome(s):

lymph node involvement

Comments on results:

Out of the 56 patients that underwent sentinel lymph node biopsy, none were found to have lymph node involvement

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your risk of bias rating

Risk of bias assessment: cohort study

Subject selection
"New technology" group
Highly selected or not described
Comparison group
Highly selected or not described
Comparability of groups on demographic characteristics and clinical features
Not comparable and not adjusted for differences
Measurement of outcomes
Outcome measures blind to technology used
No, but objective measures used
Same method of measurement used across comparison groups
Yes
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
Yes (follow-up >95%) or survival analysis using all patients
Result of appraisal

Jutta's tick icon.png Included




Completed by

Meghna Kakani


Jutta's tick icon.png This appraisal has been completed.


Article
Guadagnolo BA, Prieto V, Weber R, Ross MI, Zagars GK. The role of adjuvant radiotherapy in the local management of desmoplastic melanoma. Cancer 2014 May 1;120(9):1361-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/24142803.
Assigned to
User:Meghna.kakani
Topic area
Guidelines:Melanoma
Clinical question
Form
Form:Critical appraisal


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