Critical appraisal:Guardino JM, Khandwala F, Lopez R, Wachsberger DM, Richter JE, Falk GW 2006

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Critical Appraisal

Article being appraised

Guardino JM, Khandwala F, Lopez R, Wachsberger DM, Richter JE, Falk GW. Barrett's esophagus at a tertiary care center: association of age on incidence and prevalence of dysplasia and adenocarcinoma. Am J Gastroenterol 2006 Oct;101(10):2187-93 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17032182.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

261



Evidence ratings

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating
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Risk of bias assessment: prevalence and incidence study

Source population of patients
Highly selected (single institution) or not described
Subject (sample) selection
Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
No or not described
Result of appraisal

Jutta's tick icon.png Included



Comments

Follow up percentage not described. The authors note that patients could have gone to other centres, and therefore would not have been captured in the centre's registry.

Median follow up time of 2.8 years.

10 patients developed "high-grade dysplasia or cancer".
Of these 10 patients, 3 patients developed adenocarcinoma.
No incidence rate mentioned.

Completed by

Peter Sarich


Jutta's tick icon.png This appraisal has been completed.


Article
Guardino JM, Khandwala F, Lopez R, Wachsberger DM, Richter JE, Falk GW. Barrett's esophagus at a tertiary care center: association of age on incidence and prevalence of dysplasia and adenocarcinoma. Am J Gastroenterol 2006 Oct;101(10):2187-93 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17032182.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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