Critical appraisal:Gurski RR, Peters JH, Hagen JA, DeMeester SR, Bremner CG, Chandrasoma PT, et al 2003

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Critical Appraisal

Article being appraised

Gurski RR, Peters JH, Hagen JA, DeMeester SR, Bremner CG, Chandrasoma PT, et al. Barrett's esophagus can and does regress after antireflux surgery: a study of prevalence and predictive features. J Am Coll Surg 2003 May;196(5):706-12; discussion 712-3 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/12742201.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

25


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: group of intereset is the 25 w LGD who had surgery - 17 regressed to ND v 14 with LGD who had PPI - 1/14 regressed

But not controlled data, may all have been due to inflammn

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Reasonable (follow-up >80%)
Size of effect
2 Reason for decision: stats were done and were significant for histol regression as a whole after surgery v PPI
Relevance of evidence
2 Additional comments: LGD is a marker for risk of cancer
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Andrew Taylor MBBS MD FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Gurski RR, Peters JH, Hagen JA, DeMeester SR, Bremner CG, Chandrasoma PT, et al. Barrett's esophagus can and does regress after antireflux surgery: a study of prevalence and predictive features. J Am Coll Surg 2003 May;196(5):706-12; discussion 712-3 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/12742201.
Assigned to
User:Andrew.taylor
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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