Critical appraisal:Haidry RJ, Dunn JM, Butt MA, Burnell M, Gupta A, Green S, et al 2013

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Critical Appraisal

Article being appraised

Haidry RJ, Dunn JM, Butt MA, Burnell M, Gupta A, Green S, et al. Radiofrequency Ablation (Rfa) And Endoscopic Mucosal Resection For Dysplastic Barrett's Esophagus And Early Esophageal Adenocarcinoma: Outcomes Of Uk National Halo Rfa Registry. Gastroenterology 2013 Mar 28 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/23542069.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

12


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
Moderate risk of bias Comments: real life study based on registry. Several cancers including many who needed surgery or CRT, diagnosed after initiation of RFA.

Only 12 with LGD of whom 10 achieved CR at 12m. Specific durability in LGD pts not specifically reported

Risk of bias assessment: case series

Subject selection:
Representative of eligible patients (e.g. population-based cancer registry)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: too small to do stats and no comparitor
Relevance of evidence
2 Additional comments: only a small number of pts but effect on marker (LGD)
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Andrew Taylor MBBS MD FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Haidry RJ, Dunn JM, Butt MA, Burnell M, Gupta A, Green S, et al. Radiofrequency Ablation (Rfa) And Endoscopic Mucosal Resection For Dysplastic Barrett's Esophagus And Early Esophageal Adenocarcinoma: Outcomes Of Uk National Halo Rfa Registry. Gastroenterology 2013 Mar 28 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/23542069.
Assigned to
User:Andrew.taylor
Topic area
Guidelines:Barrett's/Management
Clinical question
Form
Form:Critical appraisal


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