Critical appraisal:Haie-Meder C, Pellae-Cosset B, Laplanche A, Lagrange JL, Tuchais C, Nogues C, et al 1993

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Critical Appraisal

Article being appraised

Haie-Meder C, Pellae-Cosset B, Laplanche A, Lagrange JL, Tuchais C, Nogues C, et al. Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases. Radiother Oncol 1993 Feb;26(2):111-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/7681997.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

216


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
Low risk of bias Comments: Large RCT. Central blinded randomisation. Frequency of FU not stated.


Size of effect
1 Reason for decision: Equivalence trial between two RT fractionations showing no difference in survival, response to treatment, duration of palliative benefit.
Relevance of evidence
1 Additional comments: Clinically relevant outcome ie survival and neurological status measured.All patients had brain CT prior to randomisation.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Associate Professor Shalini Vinod MBBS MD FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Haie-Meder C, Pellae-Cosset B, Laplanche A, Lagrange JL, Tuchais C, Nogues C, et al. Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases. Radiother Oncol 1993 Feb;26(2):111-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/7681997.
Assigned to
User:Shalini.vinod
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
Clinical question
Form
Form:Critical appraisal


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