Critical appraisal:Haie-Meder C, Pellae-Cosset B, Laplanche A, Lagrange JL, Tuchais C, Nogues C, et al 1993
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Critical Appraisal
Article being appraised
Haie-Meder C, Pellae-Cosset B, Laplanche A, Lagrange JL, Tuchais C, Nogues C, et al. Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases. Radiother Oncol 1993 Feb;26(2):111-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/7681997.
Applicable clinical question
Key Facts
Study Design
randomised controlled trial
Number of Patients:
216
Includes an economic evaluation
no
Evidence ratings
Level of evidence
II
Risk of bias
| Low risk of bias | Comments: Large RCT. Central blinded randomisation. Frequency of FU not stated. |
Size of effect
| 1 | Reason for decision: Equivalence trial between two RT fractionations showing no difference in survival, response to treatment, duration of palliative benefit. |
Relevance of evidence
| 1 | Additional comments: Clinically relevant outcome ie survival and neurological status measured.All patients had brain CT prior to randomisation. |
Result of appraisal
Included
Completed by
This appraisal has been completed.
- Article
- Haie-Meder C, Pellae-Cosset B, Laplanche A, Lagrange JL, Tuchais C, Nogues C, et al. Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases. Radiother Oncol 1993 Feb;26(2):111-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/7681997.
- Assigned to
- User:Shalini.vinod
- Topic area
- Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
- Clinical question
Section below only relevant for Cancer Council Project Officer