Critical appraisal:Han D, Han G, Zhao X, Rao NG, Messina JL, Marzban SS, et al 2015

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Critical Appraisal

Article being appraised

Han D, Han G, Zhao X, Rao NG, Messina JL, Marzban SS, et al. Clinicopathologic predictors of survival in patients with desmoplastic melanoma. PLoS One 2015;10(3):e0119716 Available from: http://www.ncbi.nlm.nih.gov/pubmed/25811671.


Applicable clinical question

Key Facts

Study Design

cohort study

Study aims:

To identify melanoma-specific factors that influence nodal metastasis and survival in a DM population within a single institution.

Number of Patients:

316

Reported outcome(s):

Recurrence and recurrence-free survival (RFS)
Overall survival (OS) and melanoma-specific survival (MSS)

Results of outcome(s):

Recurrence and recurrence-free survival
- Note that overall, 295 patients (93%) were evaluable for recurrence, while 21 patients were lost to followup
- Recurrent disease developed in 87 patients (29.5%),
- Regional recurrence developed in 23 case
- Distant metastasis developed in 33 patients
- Five-year RFS: 62.3% (95% CI: 56.6%–68.1%)

Overall survival and melanoma-specific survival
- Note that vital status was available in all 316 patients, with 111 (35.1%) known to have died
- Cause of death was known in 79 cases, and was melanoma-related in 47 cases and not melanoma-related in 32 cases
- Overall, 14.9% (47 of 316 patients) died from melanoma; 10.1% (32 of 316 patients) died from other causes; 10.1% (32 of 316 patients) died from unknown causes.
- Five-year OS: 74.5% (95% CI: 69.2%–79.7%)
- Five-year MSS: 65.1% (95% CI: 55.0%–75.3%)

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your risk of bias rating

Risk of bias assessment: cohort study

Subject selection
"New technology" group
Selected group
Comparison group
Selected group
Comparability of groups on demographic characteristics and clinical features
Not comparable and not adjusted for differences
Measurement of outcomes
Outcome measures blind to technology used
No, but objective measures used
Same method of measurement used across comparison groups
Yes
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
Yes (follow-up >95%) or survival analysis using all patients
Result of appraisal

Jutta's tick icon.png Included




Completed by

Meghna Kakani


Jutta's tick icon.png This appraisal has been completed.


Article
Han D, Han G, Zhao X, Rao NG, Messina JL, Marzban SS, et al. Clinicopathologic predictors of survival in patients with desmoplastic melanoma. PLoS One 2015;10(3):e0119716 Available from: http://www.ncbi.nlm.nih.gov/pubmed/25811671.
Assigned to
User:Meghna.kakani
Topic area
Guidelines:Melanoma
Clinical question
Form
Form:Critical appraisal


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