Critical appraisal:Hinnen P, de Rooij FW, Hop WC, Edixhoven A, van Dekken H, Wilson JH, et al 2002

From Cancer Guidelines Wiki

Critical Appraisal

Article being appraised

Hinnen P, de Rooij FW, Hop WC, Edixhoven A, van Dekken H, Wilson JH, et al. Timing of 5-aminolaevulinic acid-induced photodynamic therapy for the treatment of patients with Barrett's oesophagus. J Photochem Photobiol B 2002 Aug;68(1):8-14 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/12208031.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

26


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
High risk of bias Comments: The study looks at the pharmacokinetics of ALA and protoporphyrin IX in Barrett's subjects. Ablation was not performed and therefore this study does not contribute the understanding as to whether PDT is a useful treatment to induce regression of Barrett's mucosa. It does help understand the pharmacology of the photosensitisers

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No or not described
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: Ablation therapy not assessed.
Relevance of evidence
3 Additional comments: Photosensitiser use is part of PDT therapy and is relevant to the assessment of this technology in Barrett's ablation
Result of appraisal

Jutta's exclamation mark icon.png Excluded

Reason for decision

The study looks at the pharmacokinetics of ALA and protoporphyrin IX in Barrett's subjects. Ablation was not performed and therefore this study does not contribute the understanding as to whether PDT is a useful treatment to induce regression of Barrett's mucosa.
Paper does not meet study design inclusion criteria.


Completed by

Dr Mark Schoeman MBBS, PhD, FRACP, AGAF


Jutta's tick icon.png This appraisal has been completed.


Article
Hinnen P, de Rooij FW, Hop WC, Edixhoven A, van Dekken H, Wilson JH, et al. Timing of 5-aminolaevulinic acid-induced photodynamic therapy for the treatment of patients with Barrett's oesophagus. J Photochem Photobiol B 2002 Aug;68(1):8-14 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/12208031.
Assigned to
User:Mark.schoeman
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment