Critical appraisal:Hofstetter WL, Peters JH, DeMeester TR, Hagen JA, DeMeester SR, Crookes PF, et al 2001 2

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Critical Appraisal

Article being appraised

Hofstetter WL, Peters JH, DeMeester TR, Hagen JA, DeMeester SR, Crookes PF, et al. Long-term outcome of antireflux surgery in patients with Barrett's esophagus. Ann Surg 2001 Oct;234(4):532-8; discussion 538-9 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/11573046.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

16


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: relevant data is the 16 pts with LGD - 7/16 had regression of LGD to NDBE

No pt progressed from LGD to HGD over 5y fu

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Reasonable (follow-up >80%)
Size of effect
5 Reason for decision: hard to determine true effect for many reasons but if compare w the RFA series of Haider, it looks significant rate of going to NDBE
Relevance of evidence
2 Additional comments: LGD as endpoint
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Andrew Taylor MBBS MD FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Hofstetter WL, Peters JH, DeMeester TR, Hagen JA, DeMeester SR, Crookes PF, et al. Long-term outcome of antireflux surgery in patients with Barrett's esophagus. Ann Surg 2001 Oct;234(4):532-8; discussion 538-9 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/11573046.
Assigned to
User:Andrew.taylor
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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