Critical appraisal:Hubbs JL, Boyd JA, Hollis D, Chino JP, Saynak M, Kelsey CR 2010

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Critical Appraisal

Article being appraised

Hubbs JL, Boyd JA, Hollis D, Chino JP, Saynak M, Kelsey CR. Factors associated with the development of brain metastases: analysis of 975 patients with early stage nonsmall cell lung cancer. Cancer 2010 Nov 1;116(21):5038-46 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20629035.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

975


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Descriptive case series of patients treated with surgery for lung cancer to determine sites of failure and incidence of brain relapse.


Size of effect
4 Reason for decision: Size of effect is not relevant. This is simply a descriptive paper for incidence of brain metastases in a surgically treated population to set as background information before discussing treatment. After surgery for Stage I & II NSCLC, 5y actuarial risk of 10% for developing brain metastases.
Relevance of evidence
3 Additional comments: This is a descriptive paper for brain relapse following Rx not a paper about the effect of treatment.ie Backround paper
Result of appraisal

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Completed by

Associate Professor Shalini Vinod MBBS MD FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Hubbs JL, Boyd JA, Hollis D, Chino JP, Saynak M, Kelsey CR. Factors associated with the development of brain metastases: analysis of 975 patients with early stage nonsmall cell lung cancer. Cancer 2010 Nov 1;116(21):5038-46 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20629035.
Assigned to
User:Shalini.vinod
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
Clinical question
Form
Form:Critical appraisal


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