Critical appraisal:Hvid-Jensen F, Pedersen L, Drewes AM, Sørensen HT, Funch-Jensen P 2011

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Critical Appraisal

Article being appraised

Hvid-Jensen F, Pedersen L, Drewes AM, Sørensen HT, Funch-Jensen P. Incidence of adenocarcinoma among patients with Barrett's esophagus. N Engl J Med 2011 Oct 13;365(15):1375-83 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21995385.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

11028



Evidence ratings

Risk of bias
Low risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: prevalence and incidence study

Source population of patients
Population based
Subject (sample) selection
Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Result of appraisal

Jutta's tick icon.png Included



Comments

Danish cancer registry is greater than 98% complete.

Median follow up period of 5.2 years.

197 adenocarcinoma cases diagnosed.
1.2 (95%CI: 0.9-1.5) adenocarcinomas per 1000 person-years.
Annual risk of 0.12% (95%CI: 0.09-0.15%).
Relative risk of 11.3 (95%CI: 8.8-14.4) compared to the general population.

Completed by

Peter Sarich


Jutta's tick icon.png This appraisal has been completed.


Article
Hvid-Jensen F, Pedersen L, Drewes AM, Sørensen HT, Funch-Jensen P. Incidence of adenocarcinoma among patients with Barrett's esophagus. N Engl J Med 2011 Oct 13;365(15):1375-83 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21995385.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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