Critical appraisal:Hvid-Jensen F, Pedersen L, Drewes AM, Sørensen HT, Funch-Jensen P 2011 4

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Critical Appraisal

Article being appraised

Hvid-Jensen F, Pedersen L, Drewes AM, Sørensen HT, Funch-Jensen P. Incidence of adenocarcinoma among patients with Barrett's esophagus. N Engl J Med 2011 Oct 13;365(15):1375-83 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21995385.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

11028



Evidence ratings

Risk of bias
Moderate risk of bias Comments: Danish population study of all diagnosed cases on the pathology registry; may have missed those that were not classified. No endoscopic or surveillance protocols and no study of risk factors

Risk of bias assessment: prevalence and incidence study

Source population of patients
Population based
Subject (sample) selection
Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Reasonable follow-up (>80%)
Result of appraisal

Jutta's tick icon.png Included



Comments

Overall incidence of EAC in BE was 1.2 cases per 1000 person-years and annual risk of 0.12%; no-dysplasia was 1.0 per 1000 person years, low grade dysplasia 5.1 per 1000 person-years and high grade dysplasia 2.6 cases per 1000 person years.

Completed by

Dr Henry To


Jutta's tick icon.png This appraisal has been completed.


Article
Hvid-Jensen F, Pedersen L, Drewes AM, Sørensen HT, Funch-Jensen P. Incidence of adenocarcinoma among patients with Barrett's esophagus. N Engl J Med 2011 Oct 13;365(15):1375-83 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21995385.
Assigned to
User:Philip.craig
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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