Critical appraisal:Ichinose M, Fujimoto A, Osuga Y, Minaguchi T, Kawana K, Yano T, et al 2013

Critical Appraisal

Article being appraised

Ichinose M, Fujimoto A, Osuga Y, Minaguchi T, Kawana K, Yano T, et al. The influence of infertility treatment on the prognosis of endometrial cancer and atypical complex endometrial hyperplasia. Int J Gynecol Cancer 2013 Feb;23(2):288-93 Available from: http://www.ncbi.nlm.nih.gov/pubmed/23314282.

Applicable clinical question

In female cancer patients does the use of ovarian stimulation for oocyte retrieval increase the risk of cancer recurrence? In breast cancer patients does the hormone receptor status of the tumor influence this outcome?

Key Facts

Study Design

cohort study, risk factors

Study aims:

This study aimed to assess the effectiveness and safety of infertility treatment after
conservative therapy for endometrial cancer in the early stage and atypical complex endometrial hyperplasia (EC/ACEH) EC/ACEH, to confirm the significance of fertility-sparing therapy.

Number of Patients:

36

Results of outcome(s):

Kaplan-Meyer curve and log-rank test analysis
revealed that women who achieved live birth had a significantly lower risk of recurrence
than those without live birth. There was not a significant difference between the patients with
and without infertility treatment.
Log-rank test
analysis revealed that the recurrence rate of women with live
birth (group A) is significantly lower than that of those
without live birth, irrespective of infertility treatment (group
B + group C) (P G 0.01).