Critical appraisal:Iftikhar SY, James PD, Steele RJ, Hardcastle JD, Atkinson M 1992
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Critical Appraisal
Article being appraised
Iftikhar SY, James PD, Steele RJ, Hardcastle JD, Atkinson M. Length of Barrett's oesophagus: an important factor in the development of dysplasia and adenocarcinoma. Gut 1992 Sep;33(9):1155-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/1427364.
Applicable clinical question
Key Facts
Study Design
prevalence and incidence study
Number of Patients:
102
Evidence ratings
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| High risk of bias | Comments: Please replace this text and include any additional comments in regards to your quality rating |
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- Article
- Iftikhar SY, James PD, Steele RJ, Hardcastle JD, Atkinson M. Length of Barrett's oesophagus: an important factor in the development of dysplasia and adenocarcinoma. Gut 1992 Sep;33(9):1155-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/1427364.
- Assigned to
- User:Freddy.sitas
- Topic area
- Guidelines:Barrett's
- Clinical question
Section below only relevant for Cancer Council Project Officer
Source population of patients - not stated, but I am assuming it is patients attending the University Hospital of Nottingham.
Measurement of condition - biopsy with lab procedure described.
Follow up - 5 patients (<5%) died during the follow up period. No other mention of drop outs etc.
Mean follow up time of 54 months.
12 patients developed dysplasia, of which, 3 developed intramucosal carcinoma (mean follow up time of 18 months after developing dysplasia).
1 additional patient developed adenocarcinoma, without first developing dysplasia.