Critical appraisal:Iftikhar SY, James PD, Steele RJ, Hardcastle JD, Atkinson M 1992 3

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Critical Appraisal

Article being appraised

Iftikhar SY, James PD, Steele RJ, Hardcastle JD, Atkinson M. Length of Barrett's oesophagus: an important factor in the development of dysplasia and adenocarcinoma. Gut 1992 Sep;33(9):1155-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/1427364.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

102



Evidence ratings

Risk of bias
High risk of bias Comments: Defined BE as >5cm and high mean length of BE; dysplasia as endpoint with 4 cases of EAC

Risk of bias assessment: prevalence and incidence study

Source population of patients
Highly selected (single institution) or not described
Subject (sample) selection
Highly selected (selection at clinician's discretion regardless of whether sample consecutive), unclear or not described
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Result of appraisal

Jutta's tick icon.png Included



Comments

Exclude 3 with HGD at diagnosis. 9/99 (9%) had LGD and one progressed to EAC; 12/99 progressed to dysplasia and all had SIM of 8cm or greater. Concluded that those with longer length were more likely to progress to dysplasia

Completed by

Dr Henry To


Jutta's tick icon.png This appraisal has been completed.


Article
Iftikhar SY, James PD, Steele RJ, Hardcastle JD, Atkinson M. Length of Barrett's oesophagus: an important factor in the development of dysplasia and adenocarcinoma. Gut 1992 Sep;33(9):1155-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/1427364.
Assigned to
User:Henry.to
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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