Critical appraisal:Iftikhar SY, James PD, Steele RJ, Hardcastle JD, Atkinson M 1992 4

Critical Appraisal

Article being appraised

Iftikhar SY, James PD, Steele RJ, Hardcastle JD, Atkinson M. Length of Barrett's oesophagus: an important factor in the development of dysplasia and adenocarcinoma. Gut 1992 Sep;33(9):1155-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/1427364.

Applicable clinical question

• Are there groups of patients with BO that can be discharged from surveillance?

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

102

Evidence ratings

Risk of bias

High risk of bias

Comments: Defined BE as >5cm and high mean length of BE; dysplasia as endpoint with 4 cases of EAC

Show/Hide Risk of bias assessment

Risk of bias assessment: prevalence and incidence study

Source population of patients

Highly selected (single institution) or not described

Subject (sample) selection

Highly selected (selection at clinician's discretion regardless of whether sample consecutive), unclear or not described

Measurement of condition

Objective and reliable (based on registry or other equivalent source)

Follow-up complete and all patients included in the analysis?

Yes (follow-up >95%)

Result of appraisal

Included

Comments

Exclude 3 with HGD at diagnosis. 9/99 (9%) had LGD and one progressed to EAC; 12/99 progressed to dysplasia and all had SIM of 8cm or greater. Concluded that those with longer length were more likely to progress to dysplasia

Completed by

Dr Henry To

This appraisal has been completed.

Article

Iftikhar SY, James PD, Steele RJ, Hardcastle JD, Atkinson M. Length of Barrett's oesophagus: an important factor in the development of dysplasia and adenocarcinoma. Gut 1992 Sep;33(9):1155-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/1427364.

Assigned to

User:Philip.craig

Topic area

Guidelines:Barrett's

Clinical question

• Are there groups of patients with BO that can be discharged from surveillance?

Form

Form:Critical appraisal

Section below only relevant for Cancer Council Project Officer

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