Critical appraisal:Johansson JE, Andersson SO, Holmberg L, Bergström R 1991

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Critical Appraisal

Article being appraised

Johansson JE, Andersson SO, Holmberg L, Bergström R. Primary orchiectomy versus estrogen therapy in advanced prostatic cancer--a randomized study: results after 7 to 10 years of followup. J Urol 1991 Mar;145(3):519-22; discussion 522-3 Available from: http://www.ncbi.nlm.nih.gov/pubmed/1997702.


Applicable clinical question

Key Facts

Study Design

quasi-experimental study

Number of Patients:

150


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-1

Risk of bias
Moderate risk of bias Comments: The groups differ in disease stage (M0/M1). The medium quality rating was based on the assessmnet of a stratified analysis undertaken for M1 and M0 for survival ( an objective outcome).For other other outcomeseg cardiovascular outcomes, low quality because outcomes not assessed blind


Size of effect
4 Reason for decision: p = 0.87
Relevance of evidence
1 Additional comments: Outcomes survival, progression and cardiovascular events
Result of appraisal

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Article
Johansson JE, Andersson SO, Holmberg L, Bergström R. Primary orchiectomy versus estrogen therapy in advanced prostatic cancer--a randomized study: results after 7 to 10 years of followup. J Urol 1991 Mar;145(3):519-22; discussion 522-3 Available from: http://www.ncbi.nlm.nih.gov/pubmed/1997702.
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Guidelines:Test cancer
Clinical question
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Form:Critical appraisal


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