Critical appraisal:Kelty CJ, Ackroyd R, Brown NJ, Brown SB, Reed MW 2004

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Critical Appraisal

Article being appraised

Kelty CJ, Ackroyd R, Brown NJ, Brown SB, Reed MW. Comparison of high- vs low-dose 5-aminolevulinic acid for photodynamic therapy of Barrett's esophagus. Surg Endosc 2004 Mar;18(3):452-8 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/14752635.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

25


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3


Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: The study a dose finding study and only small numbers of patients were included. There was an attempt to make some statistical analysis between groups but the evaluation was limited to comparison of the median effect and this did not achieve statistical significance.
Relevance of evidence
2 Additional comments: PDT successfully ablates Barrett's mucosa with return of squamous mucosa.
Result of appraisal

Jutta's exclamation mark icon.png Excluded

Reason for decision

It is not focused on the treatment utility of PDT in Barrett's patients as it is a phase 1 study looking at drug dose evaluation.
Paper does not meet study design inclusion criteria.


Completed by

Dr Mark Schoeman MBBS, PhD, FRACP, AGAF


Jutta's tick icon.png This appraisal has been completed.


Article
Kelty CJ, Ackroyd R, Brown NJ, Brown SB, Reed MW. Comparison of high- vs low-dose 5-aminolevulinic acid for photodynamic therapy of Barrett's esophagus. Surg Endosc 2004 Mar;18(3):452-8 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/14752635.
Assigned to
User:Mark.schoeman
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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