Critical appraisal:Kim J, Turan V, Oktay K 2016
Kim J, Turan V, Oktay K. Long-Term Safety of Letrozole and Gonadotropin Stimulation for Fertility Preservation in Women With Breast Cancer. J Clin Endocrinol Metab 2016 Apr;101(4):1364-71 Available from: http://www.ncbi.nlm.nih.gov/pubmed/26751194.
- In female cancer patients does the use of ovarian stimulation for oocyte retrieval increase the risk of cancer recurrence? In breast cancer patients does the hormone receptor status of the tumor influence this outcome?
cohort study, risk factors
prospective, nonrandomized, controlled study
We aimed to investigate the long-term safety of FP via controlled ovarian stimulation with letrozole supplementation (COSTLES) prior to breast cancer treatment.
The primary end point was cancer recurrence defined as the detection of locoregional tumor (chest wall, regional nodal disease), distant metastases, or contralateral invasive breast cancer.
In the FP group, the hazard ratio for recurrence after ovarian stimulation was 0.77 (95% confidence interval 0.28–2.13), and the survival was not compromised compared with controls (P = .61). Neither BRCA gene mutation status (P = .57) nor undergoing FP before or after breast surgery (P = .44) affected survival outcomes in the FP group. Likewise, none of the tumor characteristics including the estrogen receptor status affected the survival rates after the COSTLES.
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- Kim J, Turan V, Oktay K. Long-Term Safety of Letrozole and Gonadotropin Stimulation for Fertility Preservation in Women With Breast Cancer. J Clin Endocrinol Metab 2016 Apr;101(4):1364-71 Available from: http://www.ncbi.nlm.nih.gov/pubmed/26751194.
- Assigned to
- Topic area
- Guidelines:COSA:Cancer fertility preservation guidelines/Options for treatment
- Clinical question
Section below only relevant for Cancer Council Project Officer