Critical appraisal:Kim MJ, Choe SA, Kim MK, Yun BS, Seong SJ, Kim YS 2019

Critical Appraisal

Article being appraised

Kim MJ, Choe SA, Kim MK, Yun BS, Seong SJ, Kim YS. Outcomes of in vitro fertilization cycles following fertility-sparing treatment in stage IA endometrial cancer. Arch Gynecol Obstet 2019 Oct;300(4):975-980 Available from: http://www.ncbi.nlm.nih.gov/pubmed/31440822.

Applicable clinical question

In cancer survivors does the use of assisted reproduction technologies increase the likelihood of cancer recurrence?

Key Facts

Study Design

case series

Number of Patients:

Not applicable

Results of outcome(s):

Women of a median age of 34 years (range 26-41 years) underwent a total of 49 embryo transfers within an average of 2 months after their last progestin treatment. The clinical pregnancy rate per transfer was 26.5%, implantation rate was 16.7%, and live birth rate was 14.3%. The cumulative clinical pregnancy rate was 50% (11/22), resulting in 6 live births (27.3%) within 3 cycles of embryo transfer. The median endometrial thickness on the day of human chorionic gonadotropin injection in 34 fresh cycles was 9.0 mm (range 4-10 mm) in live births, 7.5 mm (range 6-9 mm) in miscarriages, and 6.0 mm (range 4-15 mm) in no pregnancy cases. During a median post-cancer treatment follow-up period of 41 months (range 9-150 months), 6 (27.3%) women underwent definitive hysterectomy for EC relapse.

Includes an economic evaluation

no