Critical appraisal:Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert BG, et al 2011
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Critical Appraisal
Article being appraised
Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert BG, et al. Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol 2011 Jan 10;29(2):134-41 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21041710.
Applicable clinical question
Key Facts
Study Design
randomised controlled trial
Number of Patients:
359
Includes an economic evaluation
no
Evidence ratings
Level of evidence
II
Risk of bias
| Low risk of bias | Comments: Large RCT, central randomisation, ITT analysis, good FU |
Size of effect
| 1 | Reason for decision: RCT of adjuvant WBRT (30/10) following surgery or radiosurgery for 1-3 brain mets. Intracranial progression reduced with WBRT from 78% vs 48%. No difference in time to WHO PS>2, 9.5m vs 10m.No diff median survival 10.7m vs 10.9m. |
Relevance of evidence
| 1 | Additional comments: Endpoints of survival, functional independence, brain relapse |
Result of appraisal
Included
Completed by
This appraisal has been completed.
- Article
- Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert BG, et al. Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC 22952-26001 study. J Clin Oncol 2011 Jan 10;29(2):134-41 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21041710.
- Assigned to
- User:Shalini.vinod
- Topic area
- Guidelines:Lung cancer/Treatment/Non-small-cell stage IV operable
- Clinical question
Section below only relevant for Cancer Council Project Officer