Critical appraisal:Kroman N, Jensen MB, Wohlfahrt J, Ejlertsen B, Danish Breast Cancer Cooperative Group 2008
Critical Appraisal
Kroman N, Jensen MB, Wohlfahrt J, Ejlertsen B, Danish Breast Cancer Cooperative Group. Pregnancy after treatment of breast cancer--a population-based study on behalf of Danish Breast Cancer Cooperative Group. Acta Oncol 2008;47(4):545-9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/18465320.
Key Facts
cohort study, risk factors
An update on the question of prognostic influence of pregnancy subsequent to breast cancer treatment (additional 10 years of inclusion and observation)
10236
- Breast cancer patients <45 years
- Pregnancy
- Node positivity
- Size of tumour
- Risk of death
- 371 women (3.6%) experienced 465 pregnancies
- Significantly fewer women with subsequent pregnancy were node positive (p<0.001) and tendancy to smaller tumours (p = 0.09)
- Women with full-term pregnancy after treatment of breast cancer had significantly reduced risk of dying (RR 0.73, 95%CI 0.54 - 0.99, p=0.04) compared to other women with breast cancer
- Women experiencing miscarriage were also found to have a significant reduced risk of death (RR 0.35, 95% CI 0.15 - 0.85, P<0.05)
- Cohort extended from original 5752 patients to 10236 and additional follow-up of 10 years for the original cohort
no
Evidence ratings
III-2
| Moderate risk of bias | Comments: Please see Analysis bias |
| 1 | Reason for decision: |
| 1 | Additional comments: Risk of death very relevant |
Included
This appraisal has been completed.
- Article
- Kroman N, Jensen MB, Wohlfahrt J, Ejlertsen B, Danish Breast Cancer Cooperative Group. Pregnancy after treatment of breast cancer--a population-based study on behalf of Danish Breast Cancer Cooperative Group. Acta Oncol 2008;47(4):545-9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/18465320.
- Assigned to
- User:Sally.reid
- Topic area
- Guidelines:COSA:Cancer fertility preservation guidelines/Preconception assessment for cancer survivors
- Clinical question
Section below only relevant for Cancer Council Project Officer
- Multivariate analysis showed that the effect of subsequent pregnancy was not significantly modified by age, tumour size, nodal status, status as parous/nulliparous before diagnosis, time since most recent previous pregnancy before diagnosis, age at subsequent pregnancy, or time to subsequent pregnancy)