Critical appraisal:Kurtz JM, Gelber R, Brady LW, Carella RJ, Cooper JS 1981

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Critical Appraisal

Article being appraised

Kurtz JM, Gelber R, Brady LW, Carella RJ, Cooper JS. The palliation of brain metastases in a favorable patient population: a randomized clinical trial by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1981 Jul;7(7):891-5 Available from: http://www.ncbi.nlm.nih.gov/pubmed/6171553.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

255


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
Low risk of bias Comments: Large RCT by RTOG. Method of randomisation not stated. Adequate length and frequency of FU. Brain mets diagnosed on isotope scan.


Size of effect
1 Reason for decision: RCT of two RT fractionation schemes which did not show any difference in survival or palliative benefit between arms.
Relevance of evidence
1 Additional comments: Endpoint was survival and palliative benefit.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Associate Professor Shalini Vinod MBBS MD FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Kurtz JM, Gelber R, Brady LW, Carella RJ, Cooper JS. The palliation of brain metastases in a favorable patient population: a randomized clinical trial by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1981 Jul;7(7):891-5 Available from: http://www.ncbi.nlm.nih.gov/pubmed/6171553.
Assigned to
User:Shalini.vinod
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
Clinical question
Form
Form:Critical appraisal


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