Critical appraisal:Kurtz JM, Gelber R, Brady LW, Carella RJ, Cooper JS 1981
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Critical Appraisal
Article being appraised
Kurtz JM, Gelber R, Brady LW, Carella RJ, Cooper JS. The palliation of brain metastases in a favorable patient population: a randomized clinical trial by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1981 Jul;7(7):891-5 Available from: http://www.ncbi.nlm.nih.gov/pubmed/6171553.
Applicable clinical question
Key Facts
Study Design
randomised controlled trial
Number of Patients:
255
Includes an economic evaluation
no
Evidence ratings
Level of evidence
II
Risk of bias
| Low risk of bias | Comments: Large RCT by RTOG. Method of randomisation not stated. Adequate length and frequency of FU. Brain mets diagnosed on isotope scan. |
Size of effect
| 1 | Reason for decision: RCT of two RT fractionation schemes which did not show any difference in survival or palliative benefit between arms. |
Relevance of evidence
| 1 | Additional comments: Endpoint was survival and palliative benefit. |
Result of appraisal
Included
Completed by
This appraisal has been completed.
- Article
- Kurtz JM, Gelber R, Brady LW, Carella RJ, Cooper JS. The palliation of brain metastases in a favorable patient population: a randomized clinical trial by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 1981 Jul;7(7):891-5 Available from: http://www.ncbi.nlm.nih.gov/pubmed/6171553.
- Assigned to
- User:Shalini.vinod
- Topic area
- Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
- Clinical question
Section below only relevant for Cancer Council Project Officer