Critical appraisal:Lally BE, Zelterman D, Colasanto JM, Haffty BG, Detterbeck FC, Wilson LD 2006

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Critical Appraisal

Article being appraised

Lally BE, Zelterman D, Colasanto JM, Haffty BG, Detterbeck FC, Wilson LD. Postoperative radiotherapy for stage II or III non-small-cell lung cancer using the surveillance, epidemiology, and end results database. J Clin Oncol 2006 Jul 1;24(19):2998-3006 Available from: http://www.ncbi.nlm.nih.gov/pubmed/16769986.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

7465


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
Moderate risk of bias Comments: Not all biases could be accounted for in this study design, however the authors did do everything possible to minimise them


Size of effect
1 Reason for decision: Subset analysis but hazard ratio for N2 disease 0.855 (95%CI, 0.762-0.959, p=.0077)
Relevance of evidence
1 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

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Completed by

Lehman


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Article
Lally BE, Zelterman D, Colasanto JM, Haffty BG, Detterbeck FC, Wilson LD. Postoperative radiotherapy for stage II or III non-small-cell lung cancer using the surveillance, epidemiology, and end results database. J Clin Oncol 2006 Jul 1;24(19):2998-3006 Available from: http://www.ncbi.nlm.nih.gov/pubmed/16769986.
Assigned to
User:Margot.lehman
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage III operable
Clinical question
Form
Form:Critical appraisal


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