Critical appraisal:Larkin J, Ascierto PA, Dréno B, Atkinson V, Liszkay G, Maio M, et al 2014 2
From Cancer Guidelines Wiki
Risk of bias assessment: randomised controlled trial
Was the trial double-blinded?
- Outcomes not blinded, substantial side-effects, or not reported.
Was the treatment allocation schedule concealed?
- No concealment or unclear (e.g. no approach described, open randomisation lists, person doing recruitment tossing a coin).
Were all randomised participants included in the analysis?
- No exclusions or survival analysis used with all subjects included (>95% follow-up for all groups).
The field below is not considered when calculating the risk of bias rating
Overall risk of bias
|High risk of bias||Additional comments: not blinded, no treatment allocation described, intention to treat population|
- Larkin J, Ascierto PA, Dréno B, Atkinson V, Liszkay G, Maio M, et al. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N Engl J Med 2014 Nov 13;371(20):1867-76 Available from: http://www.ncbi.nlm.nih.gov/pubmed/25265494.
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Section below only relevant for Cancer Council Project Officer