Critical appraisal:Lee HM, Kim BW, Park S, Park S, Lee JE, Choi YJ, et al 2019

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Critical Appraisal

Article being appraised

Lee HM, Kim BW, Park S, Park S, Lee JE, Choi YJ, et al. Childbirth in young Korean women with previously treated breast cancer: The SMARTSHIP study. Breast Cancer Res Treat 2019 Jul;176(2):419-427 Available from: http://www.ncbi.nlm.nih.gov/pubmed/31020470.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

18000

Results of outcome(s):

Compared to 10,164 childbirths among 91,400 women without breast cancer (incidence rate: 22.3/1000), 855 childbirths occurred among 18,280 breast cancer survivors (incidence rate: 9.4/1000); the adjusted hazard ratio (HR) for childbirth was 0.41 (95% CI 0.38-0.44). Chemotherapy, endocrine therapy, and target therapy were associated with the decreasing childbirths among survivors, with corresponding adjusted HRs of 0.61 (0.53-0.70), 0.44 (0.38-0.51), and 0.62 (0.45-0.86), respectively. Breast cancer survivors had a lower probability of full-term delivery and a higher frequency of preterm labor than controls, with corresponding adjusted ORs of 0.78 (0.68-0.90) and 1.33 (1.06-1.65), respectively.

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
Low risk of bias Comments:
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Jessica Harris

Jutta's tick icon.png This appraisal has been completed.


Article
Lee HM, Kim BW, Park S, Park S, Lee JE, Choi YJ, et al. Childbirth in young Korean women with previously treated breast cancer: The SMARTSHIP study. Breast Cancer Res Treat 2019 Jul;176(2):419-427 Available from: http://www.ncbi.nlm.nih.gov/pubmed/31020470.
Assigned to
User:Jessica.harris
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Assisted reproduction for cancer survivors
Clinical question
Form
Form:Critical appraisal


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