Critical appraisal:Leggett CL, Gorospe EC, Calvin AD, Harmsen WS, Zinsmeister AR, Caples S, et al 2013

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Critical Appraisal

Article being appraised

Leggett CL, Gorospe EC, Calvin AD, Harmsen WS, Zinsmeister AR, Caples S, et al. Obstructive Sleep Apnea is a Risk Factor for Barrett's Esophagus. Clin Gastroenterol Hepatol 2013 Sep 11 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/24035775.


Applicable clinical question

Key Facts

Study Design

cross sectional study

Number of Patients:

361


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Single-institution medical record review among patients who had undergone upper GI endoscopy and sleep studies for the presence of OSA.

Risk of bias assessment: cross-sectional study

Subject selection
Highly selected or not described (e.g. single-institution study)
Comparability of groups analysed on demographic characteristics
Not comparable but adjusted analysis used
Participation rate
High participation rate (>80%) and no important differences between participants and non-participants
Size of effect
1 Reason for decision: A positive association was found between diagnosis of sleep apnoea and Barrett's oesophagus.


Obstructive Sleep Apnoea (multivariate OR and 95% CI)
No 1.0 (reference)
Yes 1.8 (1.1–3.2)

Relevance of evidence
1 Additional comments: While the design of the study is suboptimal and prone to certain selection biases, outcomes were determined appropriately and the measurement of sleep apnoea is relevant to patients and persons-at-risk.
Result of appraisal

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Completed by

David Whiteman


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Article
Leggett CL, Gorospe EC, Calvin AD, Harmsen WS, Zinsmeister AR, Caples S, et al. Obstructive Sleep Apnea is a Risk Factor for Barrett's Esophagus. Clin Gastroenterol Hepatol 2013 Sep 11 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/24035775.
Assigned to
User:David.whiteman
Topic area
Guidelines:Barrett's/Natural history
Clinical question
Form
Form:Critical appraisal


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