Critical appraisal:Li S, Lin H, Xie Y, Jiao X, Qiu Q, Zhang Q 2019

Critical Appraisal

Article being appraised

Li S, Lin H, Xie Y, Jiao X, Qiu Q, Zhang Q. Live Births after in vitro Fertilization with Fertility-Sparing Surgery for Borderline Ovarian Tumors: A Case Series and Literature Review. Gynecol Obstet Invest 2019;84(5):445-454 Available from: http://www.ncbi.nlm.nih.gov/pubmed/30799426.

Applicable clinical question

In cancer survivors does the use of assisted reproduction technologies increase the likelihood of cancer recurrence?

Key Facts

Study Design

case series

Number of Patients:

Not applicable

Results of outcome(s):

The study sample of 17 patients started IVF-assisted reproduction within a median of 24 months after fertility-sparing surgery. Eight patients achieved live births after IVF followed by fresh or frozen-thawed embryo transfer, and one is currently pregnant after the second IVF treatment. Four of these 17 women experienced 6 recurrences of BOTs after IVF and delivery in a median of 29 months of follow-up. The literature reports a pooled estimate of 63.5% for pregnancy and 21.7% for recurrence of BOTs in patients with the same condition. Pregnancy outcomes of IVF in these women are usually better than those of generally infertile women. Moreover, our review of the literature suggests that ART has no negative impact on the prognosis of BOTs.

Includes an economic evaluation

no