Critical appraisal:Lim CH, Treanor D, Dixon MF, Axon AT 2007

Critical Appraisal

Article being appraised

Lim CH, Treanor D, Dixon MF, Axon AT. Low-grade dysplasia in Barrett's esophagus has a high risk of progression. Endoscopy 2007 Jul;39(7):581-7 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17611911.

Applicable clinical question

• What is the incidence of neoplasia in patients with BO?

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

357

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias

High risk of bias

Comments: Please replace this text and include any additional comments in regards to your quality rating

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Risk of bias assessment: prevalence and incidence study

Source population of patients

Highly selected (single institution) or not described

Subject (sample) selection

Highly selected (selection at clinician's discretion regardless of whether sample consecutive), unclear or not described

Measurement of condition

Objective and reliable (based on registry or other equivalent source)

Follow-up complete and all patients included in the analysis?

Yes (follow-up >95%)

Result of appraisal

Included

Comments

There were 357 patients with BO. After 8 years, HGD or esophageal cancer had developed in 25/356 patients with BO. The overall incidence of cancer was 1 per 160 patient−years’ follow−up.

Completed by

Ms Qingwei Luo

This appraisal has been completed.

Article

Lim CH, Treanor D, Dixon MF, Axon AT. Low-grade dysplasia in Barrett's esophagus has a high risk of progression. Endoscopy 2007 Jul;39(7):581-7 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17611911.

Assigned to

User:Freddy.sitas

Topic area

Guidelines:Barrett's

Clinical question

• What is the incidence of neoplasia in patients with BO?

Form

Form:Critical appraisal

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