Critical appraisal:Lin C, Donaldson SS, Meza JL, Anderson JR, Lyden ER, Brown CK, et al 2012

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Critical Appraisal

Article being appraised

Lin C, Donaldson SS, Meza JL, Anderson JR, Lyden ER, Brown CK, et al. Effect of radiotherapy techniques (IMRT vs. 3D-CRT) on outcome in patients with intermediate-risk rhabdomyosarcoma enrolled in COG D9803--a report from the Children's Oncology Group. Int J Radiat Oncol Biol Phys 2012 Apr 1;82(5):1764-70 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21470795.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

375


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: cohort study

Subject selection
"New technology" group
No response
Comparison group
No response
Comparability of groups on demographic characteristics and clinical features
No response
Measurement of outcomes
Outcome measures blind to technology used
No response
Same method of measurement used across comparison groups
No response
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
No response
Size of effect
5 Reason for decision: No effect was noted on survival.
Relevance of evidence
5 Additional comments: The dosimetric charecters were better for IMRT, but no survival difference was found.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Sarat Chander FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Lin C, Donaldson SS, Meza JL, Anderson JR, Lyden ER, Brown CK, et al. Effect of radiotherapy techniques (IMRT vs. 3D-CRT) on outcome in patients with intermediate-risk rhabdomyosarcoma enrolled in COG D9803--a report from the Children's Oncology Group. Int J Radiat Oncol Biol Phys 2012 Apr 1;82(5):1764-70 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21470795.
Assigned to
User:Sarat.chander
Topic area
Guidelines:Sarcoma/Radiotherapy
Clinical question
Form
Form:Critical appraisal


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