Luman W, Lessels AM, Palmer KR. Failure of Nd-YAG photocoagulation therapy as treatment for Barrett's oesophagus--a pilot study. Eur J Gastroenterol Hepatol 1996 Jul;8(7):627-30 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/8853248.
randomised controlled trial
|High risk of bias||Comments: Abstract only reviewed. This is a pilot study in a small number of patients. There were only 4 patients in each arm. The aim of the study was primarily treatment efficacy and not safety although these data were recorded. Randomisation not described in the abstract.|
Risk of bias assessment: randomised controlled trial
- Outcomes not blinded, substantial side-effects, or not reported.
- No concealment or unclear (e.g. no approach described, open randomisation lists, person doing recruitment tossing a coin).
- No exclusions or survival analysis used with all subjects included (>95% follow-up for all groups).
The field below is not considered when calculating the risk of bias rating
|3||Reason for decision: The study was too small to statistically assess if laser therapy has any role in the ablation of Barrett's mucosa|
|6||Additional comments: The study was negative and the laser therapy was not effective in ablating the Barrett's mucosa.|
Pilot type study with too few patients to draw any meaningful conclusions. Details in abstract insufficient to assess further. I could not get hold of the full text version of the paper.
Laser therapy does not appear effective in Barrett's ablation in this very small group of subjects. I was unable to get a full text version of the paper to assess the merits of the paper in more detail.
- Luman W, Lessels AM, Palmer KR. Failure of Nd-YAG photocoagulation therapy as treatment for Barrett's oesophagus--a pilot study. Eur J Gastroenterol Hepatol 1996 Jul;8(7):627-30 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/8853248.
- Assigned to
- Topic area
- Clinical question
Section below only relevant for Cancer Council Project Officer