Critical appraisal:Luman W, Lessels AM, Palmer KR 1996

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Critical Appraisal

Article being appraised

Luman W, Lessels AM, Palmer KR. Failure of Nd-YAG photocoagulation therapy as treatment for Barrett's oesophagus--a pilot study. Eur J Gastroenterol Hepatol 1996 Jul;8(7):627-30 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/8853248.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

8


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
High risk of bias Comments: Abstract only reviewed. This is a pilot study in a small number of patients. There were only 4 patients in each arm. The aim of the study was primarily treatment efficacy and not safety although these data were recorded. Randomisation not described in the abstract.

Risk of bias assessment: randomised controlled trial

Was the trial double-blinded?
Outcomes not blinded, substantial side-effects, or not reported.
Was the treatment allocation schedule concealed?
No concealment or unclear (e.g. no approach described, open randomisation lists, person doing recruitment tossing a coin).
Were all randomised participants included in the analysis?
No exclusions or survival analysis used with all subjects included (>95% follow-up for all groups).
The field below is not considered when calculating the risk of bias rating
How was the allocation schedule generated?
Inadequate or not reported
Size of effect
3 Reason for decision: The study was too small to statistically assess if laser therapy has any role in the ablation of Barrett's mucosa
Relevance of evidence
6 Additional comments: The study was negative and the laser therapy was not effective in ablating the Barrett's mucosa.
Result of appraisal

Jutta's exclamation mark icon.png Excluded

Reason for decision

Pilot type study with too few patients to draw any meaningful conclusions. Details in abstract insufficient to assess further. I could not get hold of the full text version of the paper.

Comments

Laser therapy does not appear effective in Barrett's ablation in this very small group of subjects. I was unable to get a full text version of the paper to assess the merits of the paper in more detail.

Completed by

Dr Mark Schoeman MBBS, PhD, FRACP, AGAF


Jutta's tick icon.png This appraisal has been completed.


Article
Luman W, Lessels AM, Palmer KR. Failure of Nd-YAG photocoagulation therapy as treatment for Barrett's oesophagus--a pilot study. Eur J Gastroenterol Hepatol 1996 Jul;8(7):627-30 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/8853248.
Assigned to
User:Mark.schoeman
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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