Critical appraisal:Martinek J, Benes M, Brandtl P, Hucl T, Vasicek M, Voska L, et al 2008

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Critical Appraisal

Article being appraised

Martinek J, Benes M, Brandtl P, Hucl T, Vasicek M, Voska L, et al. Low incidence of adenocarcinoma and high-grade intraepithelial neoplasia in patients with Barrett's esophagus: a prospective cohort study. Endoscopy 2008 Sep;40(9):711-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/18698534.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

135


Includes an economic evaluation

no

Evidence ratings

Risk of bias
High risk of bias Comments: This is a prospective, single-centre cohort study.

Risk of bias assessment: prevalence and incidence study

Source population of patients
Highly selected (single institution) or not described
Subject (sample) selection
Highly selected (selection at clinician's discretion regardless of whether sample consecutive), unclear or not described
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Reasonable follow-up (>80%)
Result of appraisal

Jutta's tick icon.png Included



Comments

A single-centre cohort. Of 135 patients, 2 detected HGIN and adenocarcinoma. The study shows an incidence of HGIN/adenocarcinoma of 1/350 patient-years. The mean FUP was 5.2 years (range 2-13 years).

Completed by

Ms Qingwei Luo


Jutta's tick icon.png This appraisal has been completed.


Article
Martinek J, Benes M, Brandtl P, Hucl T, Vasicek M, Voska L, et al. Low incidence of adenocarcinoma and high-grade intraepithelial neoplasia in patients with Barrett's esophagus: a prospective cohort study. Endoscopy 2008 Sep;40(9):711-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/18698534.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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