Menon D, Stafinski T, Wu H, Lau D, Wong C. Endoscopic treatments for Barrett's esophagus: a systematic review of safety and effectiveness compared to esophagectomy. BMC Gastroenterol 2010 Sep 27;10:111 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/20875123.
- How effective is endoscopic management compared with surgical management for high grade dysplasia in patients with BO?
systematic review — randomised studies only assessing techniques of Barrett's ablation. No randomised studies assessing Surgery compared with endotherapy. 101 studies assessed. 12 comparative studies defined. Quality of the evidence is low. Offer a summary of the literature comparing safety and effectiveness of endotherapy and resection. Looks at the various techniques of Barrett's ablation. Conclusions: Endotherapy viable and effective. Safer than surgery. no long term data; data on frequency of surveillance; patient preference studies; quality of life after different endotherapies.
|Low risk of bias||Comments: recommendations made as above.|
Risk of bias assessment: systematic review
Studies included in the review
- Very thorough – included appropriate search terms and databases
- Yes – pre-specified inclusion criteria applied independently by two people
- Yes – appropriate quality issues were assessed independently by two people
- Yes – summary descriptive tables of subjects, interventions, outcomes etc are provided and estimates of treatment effect displayed
The following questions are only relevant for systematic reviews that pooled data
|2||Reason for decision: comments made relevant to the two interventions - surgery and endotherapy|
- Menon D, Stafinski T, Wu H, Lau D, Wong C. Endoscopic treatments for Barrett's esophagus: a systematic review of safety and effectiveness compared to esophagectomy. BMC Gastroenterol 2010 Sep 27;10:111 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/20875123.
- Assigned to
- Topic area
- Clinical question
Section below only relevant for Cancer Council Project Officer