Critical appraisal:Michaan N, Ben-David G, Ben-Yosef D, Almog B, Many A, Pauzner D, et al 2010
Critical Appraisal
Michaan N, Ben-David G, Ben-Yosef D, Almog B, Many A, Pauzner D, et al. Ovarian stimulation and emergency in vitro fertilization for fertility preservation in cancer patients. Eur J Obstet Gynecol Reprod Biol 2010 Apr;149(2):175-7 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20074845.
Key Facts
case-control study
To evaluate the outcome of ovarian stimulation and in vitro fertilization (IVF) in women undergoing fertility preservation prior to chemotherapy compared with healthy patients with infertility due to tubal factor.
21
dose of gonadotropins, mean estradiol and progesterone levels, length of stimulation, number of retrieved oocytes, number of 2 pronuclei zygotes, fertilization rate, and clinical pregnancy rate.
Patients in Group A underwent 22 emergency IVF cycles for fertility preservation prior to chemotherapy. The mean number of days until human chorionic gonadotropin administration was 10.4+/-4.8.
There were no significant differences in any of the main outcome measures between the two groups. Thawed embryos were transferred in four cancer patients: two patients had colon cancer, one had breast cancer and one had pseudomyxoma peritonei. Two of these four women conceived and gave birth to healthy newborns.
no
Evidence ratings
III-3
High risk of bias | Comments: |
1 | Reason for decision: suggests no different to embryos being frozen for usual infertility reasons |
2 | Additional comments: |
- Article
- Michaan N, Ben-David G, Ben-Yosef D, Almog B, Many A, Pauzner D, et al. Ovarian stimulation and emergency in vitro fertilization for fertility preservation in cancer patients. Eur J Obstet Gynecol Reprod Biol 2010 Apr;149(2):175-7 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20074845.
- Assigned to
- User:Roger.hart
- Topic area
- Guidelines:COSA:Cancer fertility preservation guidelines/Options for treatment
- Clinical question
Section below only relevant for Cancer Council Project Officer