Critical appraisal:Moncrieff MD, Kroon HM, Kam PC, Stalley PD, Scolyer RA, Thompson JF 2008

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Critical Appraisal

Article being appraised

Moncrieff MD, Kroon HM, Kam PC, Stalley PD, Scolyer RA, Thompson JF. Isolated limb infusion for advanced soft tissue sarcoma of the extremity. Ann Surg Oncol 2008 Oct;15(10):2749-56 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/18648882.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

21


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
High risk of bias Comments: Single institution series - not standardised for agent used (mix of melphalan, actinomycin, doxorubicin and cisplatin within the group) - no TNF

NB THIS IS THE ONLY AUSTRALIAN SERIES (ILI NOT ILP)

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
2 Reason for decision: multiple confounders with the agents used and if with palliative or neoadjuvant intent
Relevance of evidence
2 Additional comments: results compare with other case series but are lower (this would be expected given the absence of TNF alpa)- limb salvage of 76%, recurrence rate 45%, 57$CR, 33% PR, 10% NR. 24% amputation rate for progressive disease
Result of appraisal

Jutta's tick icon.png Included




Completed by

Associate Professor Susan Neuhaus


Jutta's tick icon.png This appraisal has been completed.


Article
Moncrieff MD, Kroon HM, Kam PC, Stalley PD, Scolyer RA, Thompson JF. Isolated limb infusion for advanced soft tissue sarcoma of the extremity. Ann Surg Oncol 2008 Oct;15(10):2749-56 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/18648882.
Assigned to
User:Susan.neuhaus
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


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