Critical appraisal:Muñoz E, Domingo J, De Castro G, Lorenzo I, García-Velasco JA, Bellver J, et al 2019

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Critical Appraisal

Article being appraised

Muñoz E, Domingo J, De Castro G, Lorenzo I, García-Velasco JA, Bellver J, et al. Ovarian stimulation for oocyte vitrification does not modify disease-free survival and overall survival rates in patients with early breast cancer. Reprod Biomed Online 2019 Nov;39(5):860-867 Available from: http://www.ncbi.nlm.nih.gov/pubmed/31564650.


Applicable clinical question

Key Facts

Study Design

cohort study, risk factors

Number of Patients:

259

early breast cancer
Results of outcome(s):

Exposed and non-exposed groups were comparable in tumour, node and metastases classification,
Nottingham grade, hormonal receptor status, tumour molecular phenotype, histology and pathology stage. The
exposed group was younger than the non-exposed. Recurrences occurred in 9/148 women (6.1%) in the exposed
group and 15/111 women (13.5%) in the non-exposed group, with no significant difference. The mean disease-free
survival time was 63.9 months (95% confidence interval [CI]: 61.5–66.4) in the exposed group and 60.6 months (95%
CI: 56.9–64.2) in the non-exposed, with no significant difference (log-rank [Mantel–Cox] test). Overall survival rates
were comparable; 2/148 (1.4%) and 4/111 (3.6%) patients died, in exposed and non-exposed groups, respectively,
during the period analysed. Mean overall survival times were 67.2 months (95% CI: 66.2–68.2) in the exposed group
and 65.9 months (95% CI: 64.0–67.9) in the unexposed, with no significant difference (log-rank [Mantel–Cox] test).

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
Moderate risk of bias Comments:
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Jessica Harris

Jutta's tick icon.png This appraisal has been completed.


Article
Muñoz E, Domingo J, De Castro G, Lorenzo I, García-Velasco JA, Bellver J, et al. Ovarian stimulation for oocyte vitrification does not modify disease-free survival and overall survival rates in patients with early breast cancer. Reprod Biomed Online 2019 Nov;39(5):860-867 Available from: http://www.ncbi.nlm.nih.gov/pubmed/31564650.
Assigned to
User:Rebecca.deans
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Options for treatment
Clinical question
Form
Form:Critical appraisal


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