Critical appraisal:Neuhaus H, Terheggen G, Rutz EM, Vieth M, Schumacher B 2012

Critical Appraisal

Article being appraised

Neuhaus H, Terheggen G, Rutz EM, Vieth M, Schumacher B. Endoscopic submucosal dissection plus radiofrequency ablation of neoplastic Barrett's esophagus. Endoscopy 2012 Dec;44(12):1105-13 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22968641.

Applicable clinical question

• What is the best endoscopic management of early oesophageal adenocarcinoma?

Key Facts

Study Design

case series

Number of Patients:

30

Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias

High risk of bias

Comments: single centre series, median follow up 17 months ESD for HGD/EOA followed by RFA for remaining Barrett's mucosa

Show/Hide Risk of bias assessment

Risk of bias assessment: case series

Subject selection:

Highly selected or not described (e.g. single-institution study)

Were the outcome measures blind to pre/post-intervention?

No, but objective measures used

Follow-up complete and all patients included in the analysis?

Yes (follow-up >95%)

Size of effect

2	Reason for decision: En-bloc resection rate 90% , R0 resection rate 39% complete remission of neoplasia 97% at median 17 months

Relevance of evidence

2	Additional comments: Please replace this text and briefly describe the reasons for your rating

Result of appraisal

Included

Completed by

Dr Farzan Fahrtash Bahin, MBBS (Hons), MPhil (Med)

This appraisal has been completed.

Article

Neuhaus H, Terheggen G, Rutz EM, Vieth M, Schumacher B. Endoscopic submucosal dissection plus radiofrequency ablation of neoplastic Barrett's esophagus. Endoscopy 2012 Dec;44(12):1105-13 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22968641.

Assigned to

User:Michael.bourke

Topic area

Guidelines:Barrett's

Clinical question

• What is the best endoscopic management of early oesophageal adenocarcinoma?

Form

Form:Critical appraisal

Section below only relevant for Cancer Council Project Officer

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