Critical appraisal:Neuhaus H, Terheggen G, Rutz EM, Vieth M, Schumacher B 2012

Article being appraised

Applicable clinical question

Study Design

case series

Number of Patients:

30

Includes an economic evaluation

no

Level of evidence

IV

Risk of bias

High risk of bias

Comments: single centre series, median follow up 17 months

ESD for HGD/EOA followed by RFA for remaining Barrett's mucosa

Subject selection:

Highly selected or not described (e.g. single-institution study)

Were the outcome measures blind to pre/post-intervention?

No, but objective measures used

Follow-up complete and all patients included in the analysis?

Yes (follow-up >95%)

Size of effect

2	Reason for decision: En-bloc resection rate 90% , R0 resection rate 39% complete remission of neoplasia 97% at median 17 months

Relevance of evidence

2	Additional comments: Please replace this text and briefly describe the reasons for your rating

Result of appraisal

Included

Completed by

This appraisal has been completed.

Article: Neuhaus H, Terheggen G, Rutz EM, Vieth M, Schumacher B. Endoscopic submucosal dissection plus radiofrequency ablation of neoplastic Barrett's esophagus. Endoscopy 2012 Dec;44(12):1105-13 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22968641.

Assigned to

User:Michael.bourke

Topic area

Guidelines:Barrett's

Clinical question

Section below only relevant for Cancer Council Project Officer