Critical appraisal:Neuhaus H, Terheggen G, Rutz EM, Vieth M, Schumacher B 2012

From Cancer Guidelines Wiki

Critical Appraisal

Article being appraised

Neuhaus H, Terheggen G, Rutz EM, Vieth M, Schumacher B. Endoscopic submucosal dissection plus radiofrequency ablation of neoplastic Barrett's esophagus. Endoscopy 2012 Dec;44(12):1105-13 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22968641.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

30


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: single centre series, median follow up 17 months

ESD for HGD/EOA followed by RFA for remaining Barrett's mucosa

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
2 Reason for decision: En-bloc resection rate 90% , R0 resection rate 39%

complete remission of neoplasia 97% at median 17 months

Relevance of evidence
2 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Farzan Fahrtash Bahin, MBBS (Hons), MPhil (Med)


Jutta's tick icon.png This appraisal has been completed.


Article
Neuhaus H, Terheggen G, Rutz EM, Vieth M, Schumacher B. Endoscopic submucosal dissection plus radiofrequency ablation of neoplastic Barrett's esophagus. Endoscopy 2012 Dec;44(12):1105-13 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22968641.
Assigned to
User:Michael.bourke
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment