Critical appraisal:Ozono S, Ishida Y, Honda M, Okamura J, Asami K, Maeda N, et al 2014

From Cancer Guidelines Wiki

Critical Appraisal

Article being appraised

Ozono S, Ishida Y, Honda M, Okamura J, Asami K, Maeda N, et al. General health status and late effects among adolescent and young adult survivors of childhood cancer in Japan. Jpn J Clin Oncol 2014 Oct;44(10):932-40 Available from: http://www.ncbi.nlm.nih.gov/pubmed/25108030.


Applicable clinical question

Key Facts

Study Design

cohort study, risk factors

Study aims:

To investigate general health status and late effects among adolescent and young adult survivors of childhood cancer.

Number of Patients:

1257

185 childhood cancer survivors; 72 siblings and 1000 general population controls
Results of outcome(s):

Suspected infertility (odds ratio: 25.1); delayed puberty (odds ratio 24.9); growth hormone deficiency (odds ratio: 23.0); and other endocrine and infertility problems were significantly more common in the childhood cancer survivors group compared with the control group

Comments on results:

Median age of diagnosis 8 years; median age at survey 23 years

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
Moderate risk of bias Comments:
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Jessica Harris

Jutta's tick icon.png This appraisal has been completed.


Article
Ozono S, Ishida Y, Honda M, Okamura J, Asami K, Maeda N, et al. General health status and late effects among adolescent and young adult survivors of childhood cancer in Japan. Jpn J Clin Oncol 2014 Oct;44(10):932-40 Available from: http://www.ncbi.nlm.nih.gov/pubmed/25108030.
Assigned to
User:Marianne.phillips
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Impact of cancer on fertility
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment