Critical appraisal:Pawlik TM, Ross MI, Prieto VG, Ballo MT, Johnson MM, Mansfield PF, et al 2006
Critical Appraisal
Pawlik TM, Ross MI, Prieto VG, Ballo MT, Johnson MM, Mansfield PF, et al. Assessment of the role of sentinel lymph node biopsy for primary cutaneous desmoplastic melanoma. Cancer 2006 Feb 15;106(4):900-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/16411225.
Key Facts
cohort study
1. To define the incidence of DM and evaluate the results of SLNB in patients with DM
2. To analyse the effect of DM histologic subtype (pure vs. mixed) on the incidence of positive SLNs at the time of selective lymphadenectomy
1850
Mixed DM: n=19
SLN Status
Characteristics Affecting Disease-Free Survival Rates
3-year acturial disease free survival
Univariate Analysis of Characteristics Affecting Disease-Free Survival Rates of 65 Patients with DM
- SLN pathologic status 0.02
- Radiation therapy: 0.18*
- Note that 20.0% of patients with DM (mixed DM, 5 of 19 [26.3%] vs. pure DM, 8 of 46 [17.4%]; P=0.41) received radiotherapy.
3-year acturial disease free survival
- Pure DM: 100%
- Non-DM: 90.5%
- Mixed DM: 78.2% (P=0.004 compared with patients with pure DM).
no
Evidence ratings
III-2
High risk of bias | Comments: Please replace this text and include any additional comments in regards to your risk of bias rating |
- Article
- Pawlik TM, Ross MI, Prieto VG, Ballo MT, Johnson MM, Mansfield PF, et al. Assessment of the role of sentinel lymph node biopsy for primary cutaneous desmoplastic melanoma. Cancer 2006 Feb 15;106(4):900-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/16411225.
- Assigned to
- User:Meghna.kakani
- Topic area
- Guidelines:Melanoma
- Clinical question
Section below only relevant for Cancer Council Project Officer