Critical appraisal:Pease NJ, Edwards A, Moss LJ 2005
From Cancer Guidelines Wiki
Article being appraised
Pease NJ, Edwards A, Moss LJ. Effectiveness of whole brain radiotherapy in the treatment of brain metastases: a systematic review. Palliat Med 2005 Jun;19(4):288-99 Available from: http://www.ncbi.nlm.nih.gov/pubmed/15984501.
Applicable clinical question
- What is the clinical benefit of radiotherapy to the brain for patients with inoperable brain metastases from NSCLC?
systematic review — Included RCT and non-RCT, all languages. Only studies where outcome measures reported.
Number of Patients:
Includes an economic evaluation
Level of evidence
Risk of bias
|Low risk of bias||Comments: Good search strategy including some translation of Non-English articles. Pre-defined templates for assessing evidence with weighting for quality. Results summarised. No MA performed due to heterogeneity of trials.|
Size of effect
|1||Reason for decision: Concluded WBRT provides modest survival benefit of up to 3 months over supportive care alone. This was only in patients with good performance status. >50% relief of pressure symptoms but less for neurological symptoms.|
Relevance of evidence
|1||Additional comments: Clinically relevant endpoints - survival, toxicity, neurological response, duration of response|
Result of appraisal
Associate Professor Shalini Vinod MBBS MD FRANZCR
- Pease NJ, Edwards A, Moss LJ. Effectiveness of whole brain radiotherapy in the treatment of brain metastases: a systematic review. Palliat Med 2005 Jun;19(4):288-99 Available from: http://www.ncbi.nlm.nih.gov/pubmed/15984501.
- Assigned to
- Topic area
- Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
- Clinical question
Section below only relevant for Cancer Council Project Officer